A trial comparing placebo, 5% and 10% minoxidil solution on the scalps of men experiencing male pattern pagkakalbo surprisingly found that the efficacy of minoxidil was not dose-dependant as 5% minoxidil was significantly more effective at regrowing hair than 10% minoxidil1.
Topical minoxidil is currently the only approved paggamot for androgenetic alopecia (male pattern pagkakalbo) na hindi binabago ang mga antas ng serum hormone, dahil ang tanging iba pang naaprubahang paggamot ay ang oral finasteride na binabawasan ang endogenous na produksyon ng potent male hormone, dihydrotestosterone2. Samakatuwid, ang paggamot na ito ay may malaking interes sa malaking komunidad ng mga lalaki na lumalaban sa androgenetic alopecia (AGA).
Kasama sa pag-aaral na ito ang kabuuang 90 lalaki na may AGA, na inilagay sa 3 grupo: 0% (placebo), 5% at 10% na paggamot na may minoxidil solution1 (para sa sanggunian, ang 5% minoxidil ay ang pinakakaraniwang available na pangkomersyong formula ng minoxidil). Ang paggamot ay tumagal ng 36 na linggo, at ang placebo group ay nakaranas ng halos walang pagbabago sa vertex (crown) at frontal hair counts1. Tulad ng inaasahan, ang 5% at 10% na mga grupo ng minoxidil ay nakaranas ng muling paglaki1. Gayunpaman, nakakagulat, ang 5% minoxidil ay 9 na beses na mas epektibo sa muling pagpapatubo ng vertex na buhok kaysa sa 10% minoxidil.1. Higit pa rito, ang 5% minoxidil ay bahagyang mas epektibo kaysa sa 10% sa muling paglago ng buhok sa harap1. Panghuli, balat irritation and hair shedding (this is observed in scalp hair prior to regrowth during minoxidil treatment) was more prominent in the 10% minoxidil group than the 5% minoxidil group1.
Ang mga natuklasang ito ay lubhang nakakagulat dahil karaniwang may kaugnayan sa pagtugon sa dosis sa pagtaas ng dosis ng gamot corresponding to an increase in the desired outcome of the drug as well as increase in side effects, not a decrease in desired outcome as observed in this study. These results indicate that there may be an optimal concentration of minoxidil solution which provides maximal hair regrowth for the scalp and increasing beyond this threshold reduces regrowth. This suggests that the higher concentrations of minoxidil like 10% and higher that can be found easily online and are often experimented with in the communities experiencing buhok pagkawala, should be avoided as they have worse safety profiles and also less benefits.
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Sanggunian:
- Ghonemy S Alarawi A., at Bessar, H. 2021. Efficacy at kaligtasan ng isang bagong 10% topical minoxidil versus 5% topical minoxidil at placebo sa paggamot ng male androgenetic alopecia: isang trichoscopic evaluation. Journal ng Dermatological Treatment. Volume 32, 2021 – Isyu 2. DOI: https://doi.org/10.1080/09546634.2019.1654070
- Ho CH, Sood T, Zito PM. Androgenetic Alopecia. [Na-update noong 2021 Mayo 5]. Sa: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Ene-. Magagamit mula sa: https://www.ncbi.nlm.nih.gov/books/NBK430924/
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